Paraneoplastic neurologic disorders
نویسندگان
چکیده
منابع مشابه
Paraneoplastic neurologic disorders: windows into neuronal function and tumor immunity.
Patients with PNDs typically exhibit rapidonset, severe, and focal neurologic disease on initial examination. Magnetic resonance imaging findings are usually normal, and medical history and physical examinations yield no obvious cause for the disorders. An occult malignancy is usually discovered as patients are followed up or when a PND diagnosis is suspected. It is believed that such malignanc...
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The term paraneoplastic neurologic disease (PND) encompasses several degenerative central or peripheral nervous system disorders that result from indirect effects of systemic cancer on elements of the nervous system. By definition, the dysfunction does not result from invasion or metastasis by tumor. The concept of a remote or indirect effect of cancer on the nervous system arose in the latter ...
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Paraneoplastic neurologic syndromes are degenerative diseases of the central or peripheral nervous system that develop in association with a systemic neoplasm without a direct invasion by tumor. The pathogenesis of this disorder has been hypothesized in the past, and now there is increasing evidence that autoimmune processes triggered by the underlying neoplasm play a major role in the pathophy...
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متن کاملOnconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain.
Paraneoplastic neurologic disorders (PNDs) are believed to be autoimmune neuronal degenerations that develop in some patients with systemic cancer. A series of genes encoding previously undiscovered neuronal proteins have been cloned using antiserum from PND patients. Identification of these onconeural antigens suggests a reclassification of the disorders into four groups: those in which neurom...
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ژورنال
عنوان ژورنال: Journal of Experimental and Clinical Medicine
سال: 2013
ISSN: 1309-4483,1309-5129
DOI: 10.5835/jecm.omu.30.03.001